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If You Only Watch One GLP-1 Video, Make It This

James Smith · 2,079 words · 10 min read

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Why I'm Talking About Peptides

0:00I spent my first eight years on social

0:01media talking about calorie deficits,

0:03about calorie counting, and ultimately

0:05helped millions of people lose weight.

0:07So, people think it's really weird that

0:08I'm constantly talking about peptides

0:10and weight loss drugs. But, there's a

0:11common recurring mistake that I'm seeing

0:13online, in person, with friends, in

0:15WhatsApp groups, and I need to address

0:17it right now. Now, it's worth noting I'm

0:18not a medical professional or a doctor,

0:20and that nothing I'm about to say is

0:21medical advice. Then continues to give

0:23medical advice. So, GLP-1 drugs are

0:25peptides. It doesn't mean that all

0:27peptides are GLP-1 drugs, but I want to

0:29explain the fact that I've been obsessed

0:31with weight loss since I was 11 years

0:32old. So, 11 years old, in school, I

0:35remember saying to the canteen ladies,

0:36"Excuse me, which of these foods are

0:37fattening?" I was a fat kid. I didn't

0:39understand why. It never occurred to me

0:41that I was eating too much for the

0:42amount I moved, although that sounds

0:43ridiculous to say now. And imagine

0:45remembering from 11 years old that my

0:47most successful weight loss diet was

0:49when I'd come home from school and just

0:50eat as many carrots as I could. Yes, as

0:52many carrots as I could. Then I thought

0:54carrots were a weight loss food. Anyway,

0:55I had a screwed-up relationship with

0:57food. I still do. My entire life, I love

1:00overeating. I eat when I'm tired. I eat

1:02when I'm in a good mood. I eat when I'm

1:03in a bad mood. I like pulling into

1:04petrol stations and just grabbing a

1:06sandwich when I'm not hungry. Food is

1:07life. I created a bit of a training

1:09addiction to help me counteract the

1:11amount that I like food. So, I played

1:13rugby. Now, I do jujitsu, whatever. And

1:15despite the fact of making millions from

1:17teaching people how to count calories

1:19sensibly, to defensively track the

1:21amount of food they're consuming, very

1:22much mimicking it to finances, my

1:24mission has stayed the same: to be

1:26obsessed with weight loss and to help

1:27people do it. And although these drugs

1:28aren't for everyone, I still think

Ozempic, Mounjaro and Retatrutide Explained

1:30there's a basic level of education

1:31necessary, whether you're going to

1:32consider this or not. First things

1:33first, the different compounds. Ozempic,

1:35known as semaglutide, is the first

1:37iteration, been studied for over 10

1:38years. Uh I've taken it, tried it, felt

1:40quite nauseous on it, but I welcomed the

1:42nausea because my life is nausea. Every

1:44single time I finish a meal, it's not

1:46like, "Oh, that dinner was lovely." It's

1:47me sitting back going, "Oh my god, who

1:49let me eat that much? Oh, I feel awful.

1:52Oh, I'm unbuttoning my jeans." Every

1:53dinner. So, it's nice not to have that.

1:55Then, the second iteration is called

1:57tirzepatide. Now, tirzepatide is also

1:58known as Mounjaro, and as far as legal

2:01prescription drugs for weight loss

2:03medications, Mounjaro sits at the top.

2:05And then, the next thing would be the

2:06gray market, introducing retatrutide.

2:10The funny thing for me here is, if you

2:12try and get a vaccine for COVID-19,

2:15get away from me. I don't want to see

2:17it. But, Chinese research chemicals from

2:19a gray market that can't be verified,

2:21hit me up. That is called cognitive

2:23dissonance. And there was a time in the

2:26video where I said, "I'm not going to do

2:27retatrutide." But then, I thought it'd

2:28be irresponsible to not try it. So, I've

2:29tried retatrutide. It's good. Truth be

2:31told, I don't find much of a difference

2:34between retatrutide and Mounjaro. I

2:36think that subjectively, because I've

2:37seen in the data that most people lose

2:40more weight with retatrutide, that part

2:41might be playing on me. But before I get

2:43into that too much, here's the the

2:44problem that I need to address, dosages.

2:46Now, for Mounjaro, the pens come in

2:48different dosages. And although this is

2:50very irresponsible of me to say this,

2:52and this is not medical advice, you go

The Mistake Everyone Is Making

2:54up strengths in pens the longer you're

2:56on it. And one of the issues is that

2:57these are incredibly expensive. So, what

2:59some people are doing is, every time a

3:01doctor prescription offers them the

3:02stronger drug, they're taking it and

3:04trying to get up to the strongest dosage

3:06pen. Now, what people then do is, with

3:08an insulin pen, they draw from the pen

3:10themselves independently. Because if you

3:12go from 2.5 mg to 5 mg, you still get

3:15the same amount of dosages if you use

3:17the pen. So, it's become common

3:18practice. Imagine you're a husband and

3:19wife, and you're both on a weight loss

3:20journey. You're both morbidly obese, but

3:22the treatment is costing you hundreds of

3:23pounds a month. What people are doing

3:25now is, they're going to get a 10 mg

3:26pen, even though both partners in the

3:28relationship only need 5 mg, they then

3:29independently draw their dose. You would

3:31want to make sure that your maths is

3:32correct on that. But anyway, for some

3:34people out there, the reason I'm even

3:35talking about that is, Big Pharma can

3:37make less money, and you can get better

3:38results. Again, not medical advice,

3:40don't listen to me, I'm a personal

3:41trainer. But the starting dose of

3:42Mounjaro is 2.5 mg. But whenever I've

3:45started or trialed these, because I've

3:47spoken publicly about the time I had to

3:48have surgery, and I knew I was going to

3:49gain weight, and I took Mounjaro, I

3:51started on half the dose that I was

3:53prescribed to begin with. Why? Because a

3:54certain percentage of people are going

3:56to have adverse reactions to this. Also,

3:58we're going to react to drugs incredibly

3:59differently. Now, what is better? And

4:01again, this comes from fat loss advice.

4:03If I start someone on a deficit, and in

4:053 weeks nothing happens, you could think

4:07that's really bad, but I would love the

4:08fact that in 3 weeks time we get to that

4:09point and go, "Hey, I was wrong. That's

4:11maintenance. Let's go lower." Because

4:12the other side of the coin would be,

4:14what if I start someone too severe a

4:16deficit? 3 weeks in, they're starving,

4:17they're irritable, they're annoyed,

4:19they're, you know, in a bad mood, and

4:20they go, "I hate dieting. I knew this

4:21was too difficult. I'm tired all the

4:23time. I'm hungry all the time." It would

4:24be better to underdose the deficit than

4:26overdose it. So, going back into these

4:28drugs, I'd rather I start week one half

4:29the dose that a doctor would even

4:31prescribe or whatever, and go, "Oh, I

4:32don't really feel it." And then titrate

4:33up from there. Because what I don't

4:35think people are talking about enough is

4:37there is the recommended dose from you,

4:38the doctors, pharmacists, whatever it

4:40is, but we all should be striving for

4:42the smallest amount of this drug

4:44possible to get the desired effect.

4:46Because 5 mg, like this pen is here, for

4:48example, could be enough to completely

4:50nuke my appetite, but that's not what I

4:51want. Even though I have used these

4:53drugs, and I do think there's an

4:54incredible benefit to a large cohort of

4:55people, we want to be taking an amount

4:57where we get the effects where there's a

4:59slight dulling appetite, and we can

5:00maintain and maybe live at maintenance

5:02or whatever. But ultimately, what is the

5:03least amount of this compound I can take

5:05to get the maximum results. Which brings

5:07me on to retatrutide. The starting dose

5:09recommended by most peptide clinics is 2

5:11and 1/2 mg. I know there are some people

5:13online that say differently, but one of

5:14the peptide clinics I bought this from

5:15recently said 2 and 1/2 mg. So, I

5:17started on Monday a few weeks ago at 0.5

5:20mg, 1/5 of the dose, and I felt it. I

5:23then went up to 1 mg, and I would even

5:25say that 1 mg of retatrutide was too

5:27much to the point that it started not

5:29just dulling my appetite, it put me in

5:31the realm of potentially not eating

5:33enough to train, perform, or recover.

5:36And I think that it's really important

5:37that we delve home to people, because

5:38there's no point sitting here going,

5:39"Don't take these. Don't take peptides.

5:41Don't ever take weight loss drugs." When

5:43instead the message could be, "Hey, if

5:44you're going to consider these, whatever

5:45you're thinking of starting, just start

5:47with a little bit less. Also, as you

5:49start to build up a tolerance to these

5:50drugs, maybe, especially if they come at

5:52a extreme expense, take them for a

5:54little bit, come off, build get rid of

5:56your tolerance, take these drugs for a

5:57bit, then come off, lose your tolerance,

5:59and then again, titrate up from using

6:01very small amounts. I know some people

6:03that will get a prescription pen at

6:04whatever level, and they will just

6:05inject on the first week of every month.

6:07So, therefore, they're going to create a

6:08meaningful deficit for the first 7 days,

6:09then they're going to go into 3 weeks of

6:11maintenance. There's also some data

6:12emerging now that some people online

6:14seem to think one of these drugs are

6:15rubbish because the second you stop

6:17taking them, you regain the weight.

6:18There aren't many drugs that you can

6:19take where they keep working after

6:21you've taken them, but maintenance

6:22dosages, for those of you looking to

6:24come off from these drugs or use them

6:25less, I would even look to take one jab

6:27every 2 weeks, then see where you go

6:28from there, then maybe move to one every

6:303 weeks. Because I don't think going to

6:31cold turkey from these drugs, in my own

6:33experience, is that good because I think

6:34your metabolism's going to be slightly

6:35down-regulated, your appetite's going to

6:36shoot back up. In the same way that we

6:38titrate up to them, I think we should

6:39titrate down, but instead of titrating

6:41dosages, I think instead we manipulate

6:43frequency. I think it's important that

6:44everyone taking these becomes their own

6:46best scientist. And I know that it

6:48doesn't always paint me in the best

How to Come Off These Drugs and Final Advice

6:49light being a personal trainer. I've got

6:50one of the world's largest fitness apps.

6:52I've had the James Smith Academy for 9

6:53years, and I've come to the reality now

6:55that where my coaching app used to be

6:57fat loss challenges and helping people

6:58their deficits, my app now just helps

7:00people track their workouts because the

7:02majority of people that could just lose

7:04weight through willpower weren't the

7:05people using my app in the first place.

7:07The majority of people using my app were

7:08those that needed help, and it's the

7:10same people that I think are going to

7:11benefit from peptides. Not all of them,

7:13just quite a lot of them. So, actually,

7:15in the last few months, we've actually

7:16now made my coaching app completely

7:17free. So, if you need somewhere to track

7:18your workouts, we give you a plan when

7:20you sign up. There's no rolling

7:21contracts, nothing. AI will write your

7:23workout. You don't have to pay me for

7:24that, but AI won't track your progress

7:26and somewhere to write down how

7:27difficult a set was. So, we pretty much

7:28do that now. With the world of weight

7:30loss drugs, I honestly think, even

7:32though it's completely obliterated my

7:34fitness business and the profit margins

7:35that we used to make, I think it's the

7:37best invention since antibiotics, which

7:38sounds crazy to say. And even though my

7:40fitness business makes a fraction of

7:41what it used to, I'm incredibly happy

7:43that the people that I've been helping

7:45for the last few years are starting to

7:46see results, which they couldn't have

7:48got from personal training. And that's

7:49just the truth of it. And I'm happy for

7:50them, I'm proud of them, and I will

7:51continue to feel that way. So, a message

7:53from me to anyone that's going to go out

7:54there and consider it, please be careful

7:55with anything you buy off the internet

7:56that isn't sourced from a pharmacy.

7:58Again, you're not going to listen to me

7:59if I say don't do it. And even if it

8:00comes from a pharmacy or not, please do

8:02start at the lowest dose possible, find

8:03the lowest amount you can use, and be

8:05sensible.

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