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0:00Your body already makes the hormone that
0:02ompic is designed to mimic. And this $1
0:05food can make your body release more of
0:07it. But here's what I didn't realize
0:09until I started digging through the
0:10research. GLP1 is really just one part
0:12of a much bigger system that your body
0:14uses to control your hunger and your
0:16satiety and your food noise. And the
0:18right foods can tap into that system at
0:21several different points. And one of
0:22these works in a completely different
0:24way. So instead of making more of that
0:26GLP-1 hormone, it may help the hormone
0:29that you've already made stick around
0:30longer, which is part of what drugs like
0:32Ompic are designed to do. Now, just to
0:34be clear, none of this means that a
0:35certain food will give you the same
0:37effect as Ompic. It won't. And I'm
0:39certainly not telling anyone to stop a
0:41GLP-1 medication that's working for
0:42them, but there are real and
0:45scientifically studied ways that a group
0:47of foods can tap into this broader
0:49system. So, in this video, I want to
0:50give you five tactics with which you can
0:53use natural foods to not only activate
0:55but reinforce the GLP1 system. And more
0:58importantly, I want to show you how to
0:59put it all together to make this work
1:01because they all work on completely
1:03different timelines and that changes how
1:05you want to use them. And at the end,
1:06I'll show you how to put it all together
1:08on one plate, starting with a food that
1:10cost about $1. And if you're new here,
1:12I'm Dr. Len Kim. I'm a double board
1:14certified physician. And on this
1:16channel, my mission is to give you the
1:17science and the practical tools to not
1:19only live longer, but to feel better
1:21today. And as always, even though I'm a
1:23physician, I'm not your physician. So,
1:26please talk to your doctor before making
1:27any changes to your health regimen, as
1:29this video is educational only and not
1:31medical advice. So, let's start with one
The Taste Receptors Hidden In Your Gut
1:33of the more surprising ways to tap into
1:35your own GLP-1 system. And it starts
1:37with something that most people don't
1:39associate with the stomach or the
1:40intestine at all, and that's taste.
1:42because your intestine can actually
1:44taste what's coming through it. And a
1:46lot of those taste receptors are bitter
1:48receptors. And bitterness isn't just a
1:50flavor, it's a signal. When bitter plant
1:52compounds reach your gut, they activate
1:54these receptors and that can trigger the
1:56release of gut hormones, including
1:58GLP-1. And GLP-1 or glucagon-l like
2:01peptide 1 is just a hormone that your
2:03gut naturally releases when you eat. It
2:06helps control your blood sugar and it
2:08slows down how quickly your food leaves
2:09your stomach. And one underappreciated
2:11fact, it sends a signal to your brain
2:13that you've eaten enough and it dials
2:16down your food noise. And researchers
2:17have actually tested this. When they
2:19activated those bitter receptors, they
2:21saw a corresponding increase in the
2:23signaling of gut hormones, including
2:25Gilopia 1 hormone. So these receptors
2:27aren't just detecting bitterness,
2:29they're actually part of a bigger system
2:31of how your gut responds to the food
2:33coming through it. So in practical
2:34terms, how do you actually get these
2:36compounds? Think of bitter greens and
2:38cruciferous vegetables. So that would be
2:40things like arugula and broccoli or
2:43Brussels sprouts. And you can also get
2:44them from things that you may already
2:46have every day. Things like coffee or
2:48dark chocolate. But there is something
2:49that we have to be aware of and it has
2:51to do with our environment. Over time
2:53we've actually bred a lot of the
2:55bitterness out of our food because
2:57bitter isn't a flavor that most people
2:59go looking for. The demand is for
3:00sweeter fruits and milder greens and
3:03vegetables that just tasted better and
3:06that's what we grew. So, some of the
3:07bitter compounds that activate these
3:09receptors aren't as abundant in our
3:11modern food supply as they once were.
The Fat Your Gut Turns Into a Fullness Signal
3:13And focusing on these foods is one way
3:15to turn up that Jellop1 signal, but it's
3:18only one part of the whole system. Your
3:20gut actually has many other ways of
3:22sending the same I've had enough message
3:24to your brain. And one of them has to do
3:26with a specific type of fat. And this
3:28one is incredibly simple. And it can
3:30change how much you eat naturally in
3:32just a matter of hours. And it's called
3:33oleic acid. The oleic acid mechanism
3:36works a little differently because GLP-1
3:38isn't working alone. It's part of a
3:40larger gut tobrain signal system that
3:42controls things like hunger and satiety.
3:45And one signal I want to highlight here
3:46is called OEA. So the way it works is
3:48when oleic acid reaches the upper part
3:51of your small intestine, your own tissue
3:53takes it and builds OEA, an
3:55oolioethanolomide.
3:57I actually don't know how to pronounce
3:58that, but I gave it my best shot. And
4:00this OEA sends us a tidy signal to your
4:03brain that tells that you've eaten
4:04enough. And it also helps stretch out
4:06the gap before you get hungry again. But
4:08you don't actually eat OEA. What you do
4:11is you eat the raw material and your gut
4:13builds it. And there's a randomized
4:14crossover trial in humans that showed
4:16this. So researchers gave people meals
4:18containing different types of oil,
4:20including oils that were much higher in
4:22oleic acid. The higher oleic acid meals
4:25produced significantly more OEA. And
4:27then 3 hours later, those people ate
4:29about 250 fewer calories at their next
4:32meal compared to the control group. So
4:34having said that, how do you actually
4:35get more oleic acid into a meal? Well,
4:38one of the easiest ways to target extra
4:40virgin olive oil. And then avocados are
4:43also rich in oleic acid. Um, and so are
4:45almonds and macadamia nuts. And that's
4:47what makes this super practical. You're
4:49not relying on one specific food. You're
4:51giving your gut the same raw materials,
4:54but through several different options,
4:56and your body does the rest. And the
The Food That Feeds Your Good Gut Bacteria
4:57next food gets us back to GLP-1 itself,
5:00but what matters here is not the food
5:01itself, but what your gut bacteria turn
5:03it into. And that food is resistant
5:05starch. So, most starches get broken
5:07down pretty quickly in your stomach and
5:09your small intestine. And they
5:10eventually end up as glucose in your
5:12bloodstream. But resistant starch
5:14doesn't do that. It actually survives
5:16your stomach and it survives most of the
5:18journey through your small intestine.
5:19And when it arrives in your colon, it
5:21gets there pretty much intact. And this
5:24is where your gut bacteria get to eat it
5:26and they ferment the resistant starch
5:28and they turn it into short chain fatty
5:30acids. Um, including the important ones
5:32they always talk about, things like
5:34acetate and butyrate. And butyrate is
5:36the one worth knowing here and I talk
5:38about it a lot in my other videos. Short
5:40chain fatty acids like butyrate tell
5:42your gut to release JLP1 and it's also
5:44the primary fuel for the cells lining
5:46your colon. they actually prefer that
5:48ahead of glucose. So unlike the bitter
5:50compounds that we talked about earlier,
5:52you're not directly triggering the
5:54signal here. What you're doing is you're
5:56feeding your gut bacteria and they make
5:58the compounds that help trigger it. And
6:00this is where the $1 food comes in as
6:02beans. Beans are one of the easiest and
6:04cheapest ways to get resistant starch,
6:07especially limema beans. But you can
6:08also get it from lentils and chickpeas.
6:11Also, oats and green bananas are a very
6:13good source of resistant starch. And
6:15another simple way to get this is to use
6:17the foods that you may already be
6:18eating, uh, things like rice or
6:21potatoes, and you cool them overnight in
6:23your fridge, and then you reheat them
6:25the next day. The cooling process forces
6:27some of that starch to reorganize into
6:30resistant starch, and reheating them
6:31doesn't completely undo it. There was a
6:33randomized crossover trial where
6:35researchers had participants consume
6:36either resistant starch or regular
6:39cornstarch for 4 weeks, and then they
6:41measured their response to a meal. and
6:43the resistant starch group had a
6:44significantly higher active GLP-1 after
6:47eating. But this is where timing is very
6:49important. Uh it actually takes several
6:51weeks for your gut bacteria to
6:53reorganize and be able to efficiently
6:55ferment resistant starch into those
6:57beneficial short- chain fatty acids like
6:59butyrate and acetate. So this isn't
7:01something I judge after eating beans for
7:03a week. It's almost like growing a
7:05garden, but instead of plants, you're
7:07cultivating the right bacteria to turn
7:09your food into the right signals. Now,
The Acid That Changes What Happens After a Meal08:20 How To Make GLP-1 Last Longer
7:11the next concept also has to deal with
7:13short- chain fatty acids, but this one
7:15lets you skip that whole process.
7:17Instead of waiting for your gut bacteria
7:19to make it, you can get it directly from
7:21something you eat. And I'm talking about
7:23acetic acid, which is the main acid in
7:25vinegar. So, acetic acid itself is a
7:27short chain fatty acid, uh, the same
7:30family of compounds that your gut
7:31bacteria were just making from resistant
7:33starch, except this time you don't have
7:35to wait for your gut bacteria to make
7:37it. You can get it directly from
7:38vinegar. And what's interesting about
7:40vinegar is that it seems to work through
7:41a different part of this entire system.
7:43In randomized control trials, when
7:45people consume vinegar with a
7:47carbohydrate containing meal, their
7:49blood sugar and their insulin response
7:51afterwards was lower. So, this is not
7:52the same and not the same magnitude, but
7:55it parallels what we see with JP1 drugs.
7:57And it's incredibly easy to use. You can
7:59add vinegar to a salad dressing or
8:01vegetables, or you can just incorporate
8:03into a meal that you're already eating.
8:05And a lot of people like to use apple
8:07cider vinegar as a drink before carb
8:09heavy meal. I actually made a separate
8:10video on this whole topic and I'm going
8:12to post a link in the description below.
8:13And this comes up every time I talk
8:15about this topic. It doesn't have to be
8:17apple cider vinegar. Most vinegar
8:19contain acidic acid. All right, so now
8:21we're starting to complete our entire
8:23system, but there's still one big piece
8:26that's missing. Your natural GLP1 has a
8:28halflife of only about 2 minutes.
8:30There's an enzyme in your blood called
8:32DPP4 whose entire job is to find that
8:35hormone and take it apart which is a big
8:37problem if you're trying to raise it
8:38with food. And this is exactly the
8:40problem that these medications solved.
8:42Semaglutide is engineered to
8:44specifically survive that enzyme. And
8:46that's one part of why that drug can
8:48produce a much stronger and
8:50longerlasting effect. But there's
8:51another natural way to approach the same
8:53problem. And this is where dairy protein
8:55gets really interesting. When your body
8:57digests protein from dairy, it breaks
8:59them down into smaller pieces called
9:01peptides. And some of those peptides
9:03have been shown to inhibit that DPP4
9:06enzyme, not shut it down completely, but
9:08slow it down. So instead of helping your
9:10body make more GLP1, this works from the
9:13other side. You're potentially slowing
9:15down the enzyme that's breaking it
9:16apart, which could help some of the GLP1
9:19stick around longer. And you don't need
9:21anything exotic here. Um, some of my
9:23favorites would be things like Greek
9:24yogurt or cottage cheese or keafir. And
9:27just to be clear, a serving of dairy is
9:28not going to get you the same effect of
9:30a drug. But these foods are also full of
9:33proteins and probiotics, which
9:35reinforces the whole system that we
9:37built. And now that we have all five
9:39pieces, here's what this could actually
9:40look like on a plate. So, the way I
9:42build it is you take a simple meat to
9:44start. Um, something like grass-fed beef
9:47or chicken or fatty fish. And then you
9:49can add beans like black beans, uh,
9:52which you can get a can for a dollar.
9:54Um, or edamame or whatever your favorite
9:56bean is. And then you just pair it with
9:58something bitter like arugula salad with
10:00extra virgin olive oil and vinegar based
10:02dressing. And then maybe some Greek
10:04yogurt on the side. And that's it. you
10:07now have a meal that's hitting this
10:08entire system from several different
10:10directions. And you don't have to make
10:12this exact same meal. You could use
10:14lentils or chickpeas instead of beans um
10:17and avocado instead of olive oil. Or you
10:19can use different bitter vegetables or
10:21kafir instead of yogurt. And none of
10:23these foods are going to produce the
10:24same effect of a drug like ompic or
10:27wiggoi, but they don't have to. This is
10:29just a simple way to create a system
10:31where your body releases more of its own
10:33GLP1 and a system that helps it stick
10:36around longer while also strengthening
10:38many other signals that control satiety
10:40and appetite and food noise. Once you
10:42zoom out, GLP1 is just one signal in a
10:45much bigger network. All right, I hope
10:46this was helpful. Stay healthy and I'll
10:48see you the next